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2025, 05, v.51 1-9+23
肠道微生态在炎症性肠病发病机制中的研究进展
基金项目(Foundation): 国家自然科学基金资助项目(82370532,82341219)
邮箱(Email): liuzhanju88@126.com;
DOI: 10.13885/j.issn.1000-2812.2025.05.001
摘要:

肠道微生态与炎症性肠病(IBD)的发病机制密切相关。肠道微生态可以对宿主产生各种影响,维持肠道稳态,而菌群失调参与了许多肠道疾病的发生,如IBD。随着实验方法和组学技术的进步,研究人员对肠道微生态影响IBD发病的确切机制有了更深入的理解,确定了更多微生物及其代谢物作为IBD的诊断和治疗靶点,并开发了新兴的治疗技术,为IBD的管理提供了新方案。本综述总结了当前IBD发生时肠道微生态变化研究进展,阐明了它们对疾病进展的影响,强调了其作为诊断和治疗工具的潜力,并展望了IBD的未来研究方向和创新治疗方法。

Abstract:

Gut microbiota is closely related to the pathogenesis of inflammatory bowel disease(IBD). Disruptions in gut microbiota prompt a pro-inflammatory state, contributing to the development of IBD. With advances in experimental methods and histologic techniques, a deeper understanding has been gained of the exact mechanisms by which gut microbiota influences the pathogenesis of IBD, more microorganisms and their metabolites have been identified as diagnostic and therapeutic targets for IBD, and emerging therapeutic technologies developed to provide new options for IBD management. In this review, we summarized the current evidence regarding gut microbiota alterations during IBD onset, examined their detrimental effects on disease progression, and highlighted their potentials as diagnostic and therapeutic tools. In addition, we explored future research directions and innovative treatment strategies to optimize the management of IBD.

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基本信息:

DOI:10.13885/j.issn.1000-2812.2025.05.001

中图分类号:R574

引用信息:

[1]谢湘琪,刘占举.肠道微生态在炎症性肠病发病机制中的研究进展[J].兰州大学学报(医学版),2025,51(05):1-9+23.DOI:10.13885/j.issn.1000-2812.2025.05.001.

基金信息:

国家自然科学基金资助项目(82370532,82341219)

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