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目的 探讨乙型肝炎肝硬化患者的脑功能网络拓扑属性改变及功能连接异常，并评估其拓扑学特征与患者认知表现的关联。方法 纳入兰州大学第一医院感染科2023年11月—2024年11月经临床确诊的乙型肝炎肝硬化患者32例作为乙型肝炎肝硬化组，招募健康志愿者31例为对照组，所有受试者均接受头部磁共振成像扫描和规范的神经心理学测试。采用联影科研平台、MATLAB R2024a软件分析三维T1加权成像及血氧水平依赖功能磁共振成像数据，并比较两组之间的网络拓扑属性和功能连接差异，分析网络拓扑学特征与认知评分之间的相关性。结果 与对照组相比，乙型肝炎肝硬化组的平均局部效率（F=6.316,P=0.015）、平均聚类系数（F=5.187,P=0.026）显著降低，部分脑区节点的拓扑属性呈降低趋势，但经多重比较校正后，差异均无统计学意义（P>0.05），功能连接分析显示肝硬化组存在1个连接显著增强和2个连接显著降低的子网络（P<0.05）。结论 乙型肝炎肝硬化患者存在脑功能网络拓扑组织损害，脑网络水平分析有助于了解肝硬化患者发生认知功能缺陷的神经病理学机制。
Abstract：Objective To investigate whether alterations in topological properties of brain functional networks and abnormal functional connectivity occur in patients with hepatitis B cirrhosis, and to evaluate the association between these topological features and cognitive performance in cirrhotic patients. Methods This study enrolled 32 clinically diagnosed patients with hepatitis B cirrhosis(from the Department of Infectious Diseases, The First Hospital of Lanzhou University, November 2023 to November 2024) as the cirrhosis group, along with 31 healthy volunteers recruited as the control group. All participants underwent brain magnetic resonance imaging(MRI) scanning and comprehensive neuropsychological assessments. The United Imaging Intelligence and MATLAB R2024a were utilized to analyze 3D T1-weighted imaging and blood oxygen level-dependent functional magnetic resonance imaging data. Differences in network topological properties and functional connectivity between the two groups were compared, and correlations between topological features and cognitive performance in cirrhosis patients were analyzed. Results Compared to the control group, hepatitis B cirrhosis patients exhibited significant reductions in mean local efficiency(F=6.316, P=0.015) and clustering coefficient(F=5.187, P=0.026). A decreasing trend in topological properties was observed in specific nodes, though these differences were not statistically significant after multiple comparison corrections(P>0.05). Cirrhosis patients exhibited one subnetwork with significantly enhanced functional connectivity and two subnetworks with significantly reduced functional connectivity(P<0.05). Conclusion Hepatitis B cirrhosis disrupts the topological organization of brain functional networks. Analysis of the brain network level may contribute to a more comprehensive and macro-level understanding of the neuropathological mechanisms underlying cognitive deficits in these patients.
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基本信息:
DOI：10.13885/j.issn.2097-681X.2025.07.006
中图分类号:R512.62;R575.2
引用信息:
[1]任虎玲,苟露斌,高玉岭等.乙型肝炎肝硬化患者脑功能改变的图论分析[J].兰州大学学报(医学版),2025,51(07):38-45.DOI:10.13885/j.issn.2097-681X.2025.07.006.
基金信息:
甘肃省科技计划资助项目（20JR11RA026）; 兰州市科技计划资助项目（2024-9-107）; 兰州大学第一医院院内基金资助项目（ldyyyn2023-96）