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目的 探讨甘肃省成年人群不同促甲状腺激素（TSH）水平与握力、相对握力的相关性，分析年龄、性别等因素对该关联的影响。方法 纳入甘肃省甲状腺疾病、碘营养和糖尿病全国流行病学调查随访数据，共980名成年人作为研究对象，其中男性498人，女性482人，测量握力并计算相对握力。通过多元线性回归、二元Logistic回归等方法，探讨TSH水平与握力、相对握力的关联，并调整年龄、体重、身高、尿酸等混杂因素。结果 男性握力高于女性，TSH水平低于女性（P <0.05）。TSH仅对男性的绝对握力及相对握力呈负向影响（Beta=-0.089～-0.122,P <0.05）。以TSH Q1组为参考，男性Q4组低握力风险升高（OR=2.472,95%CI:[1.121,5.451],P=0.025）；女性各TSH分组与低握力风险关联差异均无统计学意义（P> 0.05）。结论 甘肃省成年人群中TSH水平与握力、相对握力的关联存在性别差异，高TSH水平与低握力风险升高相关，该关联在男性中更显著。
Abstract：Objective To investigate the correlation between different levels of thyroid-stimulating hormone(TSH) and handgrip strength as well as relative grip strength among adults in Gansu Province, and to analyze the impact of age and sex on this association. Methods A total of 980 adults(498 males, 482 females) from the Gansu follow-up cohort of the Thyroid, Iodine Nutrition and Diabetes Epidemiology study were included. Handgrip strength was measured and Relative Grip Strength was calculated. Stepwise regression and binary logistic regression were used to examine the associations of TSH with handgrip strength and Relative Grip Strength, with adjustment for age, body weight, height, and uric acid. Results Males had a significantly higher Handgrip Strength but lower TSH than females(P < 0.05). TSH was negatively associated with Handgrip Strength And Relative Grip Strength only in males(Beta:-0.089 to-0.122, all P < 0.05). Using TSH Q1 as a reference, the elevated low-grip risk was observed in male Q4 group(OR = 2.472, 95% CI: [1.121, 5.451], P = 0.025); no significant association was found in females across all TSH quartiles(P > 0.05). Conclusion Among adults in Gansu Province, there exists a gender difference in the association between TSH levels and grip strength, with higher TSH levels linked to an increased risk of low grip strength, particularly in males.
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基本信息:
DOI：10.13885/j.issn.2097-681X.T20260046
中图分类号:R195
引用信息:
[1]张金霞,路翔,李春燕,等.不同TSH水平与握力、相对握力的相关性研究[J].兰州大学学报(医学版)().DOI:10.13885/j.issn.2097-681X.T20260046.
基金信息:
国家重点研发计划资助项目（2023YFC3503400）; 甘肃省自然科学基金资助项目（22JR5RA914）; 甘肃省联合科研基金资助项目（23JRRA1490）; 兰州市科技发展指导性计划资助项目（2019-ZD-38）; “十四五”项项目立项课题资助（2023YF2508305）; 中西医协同慢病管理研究资助项目（CXZH2024082）
2026-11-06
2026-11-06
2026-11-06